Duke University;The Regents of the University of California
发明人:
Wolfgang Liedtke,Martin Steinhoff,Farshid Guilak
申请号：
US15624508
公开号：
US20180022740A1
申请日:
2017.06.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPV4 inhibitor. Further provided are compositions including a TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application. Further provided is a transgenic mouse whose genome includes deletions of the Trpv4 gene in keratinocytes of the epidermis, wherein said transgenic mouse is a knockout for the Trpv4 gene in keratinocytes of the epidermis following keratinocyte-specific activation and expression of a site-specific recombination enzyme.
