The present invention provides a fabricating method of silicone hydrogel for ophthalmic application. The method comprises the following steps. Step (S1) is to perform a first polymerization to polymerize at least one non-silicon-containing component in order to form non-silicon-containing polymers. Step (S2) is to mix the non-silicon-containing polymers with at least one silicon-containing component in order to form a composition. And step (S3) is to perform a second polymerization and cure the composition.本發明提供一種應用於眼科物件之矽水凝膠的製造方法，包含以下步驟：(S1)將至少一種不含矽單元進行第一聚合反應，形成不含矽聚合物；(S2)將不含矽聚合物與至少一種含矽單元混合，形成組成物；以及(S3)將組成物進行第二次聚合反應並固化。
