INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DAY, JONATHAN,PATTERSON, JAMES,CHABENNE, JOSEPH,DIMARCHI, MARIA,DIMARCHI, DAVID,SMILEY, DAVID,DIMARCHI, RICHARD
申请号：
PE2013000081
公开号：
PE20140159A1
申请日:
2008.02.14
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Regarding the non-native glucose cucumber, including the sequence of SEQ ID No. 55 and one of its analyses, in this sequence, this kind of analysis is unnatural, different from the amino acids selected from positions 1, 2, 3, 5, 7, 10, 11, 13, 14, 17, 18, 19, 21, 24, 27, 28 and 29 by SEQ ID No. 55 for 1 to 3 times. Cucumber has a polyglycol chain covalently with the remaining amino acids at positions 16, 17, 21,The molecular weight of the substance is between 1000 and 40000 daltons. This kind of glucose toxicology analysis is very active for GLP-1 glucose receptor. He also mentioned a pharmacology composer who was useful in the treatment of hyperglycemia and obesity.REFERIDA A UN PEPTIDO DE GLUCAGON NO NATIVO QUE COMPRENDE LAS SECUENCIAS SEQ ID NO: 55 Y UN ANALOGO DEL MISMO, DONDE DICHO ANALOGO NO ES NATURAL Y DIFIERE DE SEQ ID NO: 55 POR 1 A 3 MODIFICACIONES DE AMINOACIDOS SELECCIONADOS DE LAS POSICIONES 1, 2, 3, 5, 7, 10, 11, 13, 14, 17, 18, 19, 21, 24, 27, 28 Y 29. DICHO PEPTIDO POSEE UNA CADENA DE POLIETILENGLICOL LIGADA COVALENTEMENTE A UN RESIDUO DE AMINOACIDO EN LA POSICION 16, 17, 21 , 24 Y EN EL AMINOACIDO C-TERMINAL Y QUE TIENE UN PESO MOLECULAR DE 1.000 A 40.000 DALTON. DICHOS ANALOGOS AGONISTAS DE GLUCAGON TIENEN ACTIVIDAD SOBRE EL RECEPTOR DE GLUCAGON GLP-1. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y SON UTILES EN EL TRATAMIENTO DE LA HIPERGLUCEMIA Y OBESIDAD.
