THE CBR INSTITUTE FOR BIOMEDICAL RESEARCH, INC.;DYAX CORP.
发明人:
RONDON, ISAAC J.,SHIMAOKA, MOTOMU,SPRINGER, TIMOTHY A.,COHEN, EDWARD H.
申请号：
CA2554965
公开号：
CA2554965C
申请日:
2005.02.22
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Leukocyte integrin LFA-1 is known to bind a number of cognateligands including inflammation-associated cell surface molecule 1(ICAM-1). LFA-1 is a protein which comprises an integrin-I domain,which has a high ligand affinity when in an open / active conformation.Disclosed herein are antibodies that bind specifically to LFA-1 when inthe open / active conformation, and not the closed / inactiveconformation.
