ФУНДАСИОН ПАРА ЛА ИНВЕСТИГАСИОН БИОМЕДИКА ДЕЛЬ ОСПИТАЛЬ УНИВЕРСИТАРИО Рамон И КАХАЛЬ (ES)
发明人:
АГВАДО ФРАЙЛЕ Элия (ES),РАМОС МУНЬОС Мирен Эдурне (ES),КАНДЕЛА ТОА Анхель Мануэль (ES),ЛИАНЬО Гарсиа Фернандо (ES),ГАРСИА БЕРМЕХО Мария Лаура (ES)
申请号：
RU2014123753
公开号：
RU2014123753A
申请日:
2012.12.11
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method for obtaining data that may be used for diagnosis and / or prognosis of acute kidney injury, which comprises determining the expression level of at least one miRNA selected from miR-26b, miR-29a, miR-454, miR-146a, miR- 27a, mi-R93 and miR-10a, in a sample collected from patsienta.2. A method of diagnosis and / or prognosis of acute kidney injury, comprising a method according to Claim. 1 and comparing said expression level with a reference value, wherein the change in said level of expression is indicative of acute pochek.3 damage. A method of diagnosis and / or prognosis of acute kidney injury according to any one of claims. 1 or 2, wherein the test sample is selected from blood, serum or mochi.4. A method of diagnosis and / or prognosis of acute kidney injury claim. 2, where a decrease in the serum level of expression of miR-26b, miR-29a, miR-454, miR-146a, miR-27a, mi-R93, and / or miR- 10a in comparison with the reference value is indicative of acute pochek.5 damage. A method of diagnosis and / or prognosis of acute kidney injury according to any one of claims. 1 or 2, wherein the miRNA expression was determined by quantitative PTSR.6. A method according to any one of claims. 1 or 2, wherein the expression level of microRNA determined using RNA mikrochipov.7. A method according to any one of claims. 1 or 2, characterized in that it comprises determining the expression levels of miR-26b, miR-29a, miR-454, miR-146a, miR-27a, mi-R93 and miR-10a odnovremenno.8. A method according to any one of claims. 1 or 2, wherein a reduction in the level of expression of at least one miRNA is indicative of acute pochek.9 damage. Use of at least one miRNA selected from miR-26b, miR-29a, miR-454, miR-146a, miR-27a, mi-R93 and miR-10a, for the diagnosis and prognosis of acute pochek.10 damage. Use of miR-26b, miR-29a, miR-454, miR-146a, miR-27a, mi-R93 and miR-10a, simultaneously, for the diagnosis and prognosis of acute pochek.11 damage. Set of reagents for the diagno
