包含免疫原性蛋白質及組合佐劑並用以誘發抗原特異性T細胞反應之疫苗組成物农业专利-农业学术服务平台

发明人:: WU, CHIA-MAO,吴嘉茂,吳嘉茂,WU, JIUN-MING,吴俊明,吳俊明,CHIU, YI-TSUI,邱怡翠,LIN, YIN-CHING,林吟璟,CHUANG, HSIEN-KAI,庄贤凯,莊賢凱,HSIEH, FU-TAN,谢馥檀,謝馥檀,CHEN, KUAN-MING,陈冠铭,陳冠銘

摘要：: Vaccine compositions for use in inducing enhanced antigen-specific T cell-mediated immune responses in a subject in need thereof are disclosed. The composition comprises (a) a therapeutically effective amount of an immunogenic protein comprising at least an antigen of a pathogen； (b) a saponin-base adjuvant selected from the group consisting of GPI-0100, Quil A, QS-21； and (c) a Toll-like receptor (TLR) agonist adjuvant selected from the group consisting of monophosphoryl lipid A (MPL), and CpG1826.本發明提供用以在需治療患者身上誘發經強化之抗原特異性T細胞介導免疫反應之疫苗組成物。該組成物包含(a)一治療有效量之一免疫原性蛋白質，其係包含至少一病原體的一抗原；(b)一皂素基佐劑(saponin-base adjuvant)，其係選自以下項目所構成群組：GPI-0100、Quil A及QS-21；以及(c)一類鐸受體致效佐劑[Toll-like receptor (TLR) agonist adjuvant]，其係選自以下項目所構成群組：單磷醯脂質A(MPL)及CpG1826。