#$%^&*AU2020101588A420200910.pdf#####Abstract of Description The present invention provides a kind of delivery molecule and nanoparticle, its preparation method, and the use. The delivery molecule consists of a cell-penetrating peptide, wherein, the poly-L-arginine is linked to the C-terminal or the N-terminal of the cell-penetrating peptide. The delivery molecules can be combined with nucleotides, such as siRNA, and proteins, DNA to form nanoparticles with a diameter of 600nm. The nanoparticles can be transfected into cells and bodies of animal models, and deliver the siRNA into cells, thus the siRNA is released to play a therapeutic role. The present invention manifests that the delivery molecule described in the present invention can deliver the deliverables into the cell or animal body at the cellular level or at the animal level, and release the deliverables to play a role. The delivery molecule is non-toxic and has high delivery efficiency.10** siRNA-GFP x3sRNA-NP(2.Spmol) 10 siRNA-NP(Spmol) M siRNA-NP(10pmol) m siRNA-NP(20pmol) 103 FIG. 5 1PBS -m- siGFP N-A- sNP(10pmol) J100. -q- siNP(50pmol) 3 Days (post-challenge) FIG.6 3/4
