Disclosed herein is a genetically modified plant of genus humulus not requiring flowering for producing lupulin glands comprising secondary compounds. Provided herein is a new plant of genus humulus having lupulin glands on non-flowering parts of the plant, such as leaves. The disclosed plants have a high mass% of secondary compounds and a high degree of lupulin glands coverage on the surface of the plant. Also disclosed herein are methods of producing secondary compounds from a plant of genus humulus without flowering the plant of genus humulus. For example, the disclosed methods provide for inducing lupulin glands development on a plant of genus humulus without flowering the plant of genus humulus.
