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Средство, обладающее иммуномодулирующей активностью
专利权人:
Federalnoe gosudarstvennoe byudzhetnoe nauchnoe uchrezhdenie "Tomskij natsionalnyj issledovatelskij meditsinskij tsentr Rossijskoj akademii nauk" (Tomskij NIMTS)
发明人:
Danilets Marina Grigorevna,Данилец Марина Григорьевна,Gurev Artem Mikhajlovich,Гурьев Артем Михайлович,Trofimova Evgeniya Sergeevna,Трофимова Евгения Сергеевна,Ligacheva Anastasiya Aleksandrovna,Лигач
申请号:
RU2017102857
公开号:
RU0002657819C1
申请日:
2017.01.27
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
FIELD: pharmaceuticals.SUBSTANCE: invention relates to the pharmaceutical industry, namely to the use of a complex of water-soluble polysaccharides with a molecular weight of 1151, 615 and 41 kD, isolated from the grass of an aquatic plant of duckweed, as a means for selectively activating immunological reactions of the Th1 type, stimulation of production of Th1 specific cytokines IL-12, TNF-α and IFN-γ. Use of a complex of water-soluble polysaccharides with a molecular mass of 1151, 615 and 41 kDa, isolated from the grass of an aquatic plant of duckweed, as a means for selectively activating Th1-type immunological reactions, stimulating the production of Th1 specific IL-12 cytokines, TNF-α and IFN-γ, obtained by extracting the grass with a solution of purified water and concentrated HCl with pH 4.0 when heated in a boiling water bath and periodically stirred, filtered and evaporated on a rotary evaporator to 1/5 of the original volume, with the addition of a three-fold volume of 96 % ethanol and settling, followed by filtration of the precipitate through a paper filter and dissolving in purified water, while stirring with a magnetic stirrer, separating the undissolved residue by centrifugation, dialyzing the supernatant through a semipermeable membrane, and stirring with a magnetic stirrer, further freezing the resulting solution and freeze-drying it under certain conditions.EFFECT: above-described complex of water-soluble polysaccharides is effective as a means for selectively activating Th1-type immunological reactions, stimulating production of Th1 specific cytokines IL-12, TNF-α and IFN-γ.1 cl, 3 ex, 7 tblИзобретение относится к фармацевтической промышленности, а именно к применению комплекса водорастворимых полисахаридов с молекулярной массой 1151, 615 и 41 кДа, выделенных из травы водного растения ряски малой, в качестве средства для избирательной активации иммунологических реакций Th1-типа, стимуляции продукции Th1 специфических цитокинов ИЛ-12, ФНО-α и ИФН
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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