The present invention relates to pharmaceutical preparations for the treatment or the prevention of a Staphylococcal infection. They contain at least one polypeptide epitope, wherein said at least one polypeptide epitope induces protective antibodies in a patient in need thereof. The polypeptide epitopes according to the present invention can preferably be used for the preparation of a vaccine against a Staphylococcal infection, such as Staphylococcus aureus, including Staphylococcus aureus (MRSA). The present invention further relates to monoclonal antibodies capable of recognizing and binding to a polypeptide epitope according to the present invention, and the invention also relates to the use of the monoclonal antibodies for diagnosis and the prevention or therapy of Staphylococcal infection, including MRSA.
