NAIDU, B. Narasimhulu,PATEL, Manoj,CONNOLLY, Timothy P.
申请号：
ES14727271
公开号：
ES2623904T3
申请日:
2014.03.13
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula I or formula II ** Formula ** in which: R1 is -CON (R7) (Rs)； or R1 is pyrrolyl, furanyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, indolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, or phenyl, and is substituted with 0-3 substituents, halo, alkyl, haloalkyl, alkenyl, alkoxy, alkenoxy, Ar1, (Ar1) alkyl, and (Ar1) O； R2 is hydrogen or alkyl； R3 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, cycloalkyl, hydroxy, alkoxy, haloalkoxy, alkenyloxy , and phenyl； or R3 is cycloalkyl, cycloalkenyl, chromanyl, oxacinyl, or dihydropyranoquinolinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, cycloalkyl, hydroxy, alkoxy, haloalkoxy, alkenyloxy, and phenyl； R4 is alkyl or haloalkyl； R5 is alkyl； R6 is hydrogen or alkyl； R7 is Ar1 or (Ar1) alkyl； R8 is hydrogen or alkyl； Ar1 is phenyl or pyridinyl and is substituted with 0-3 substituents selected from halo, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, and alkenyloxy； x1 is -CONH-； or X1 is pyrrolyl, furanyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, benzimidazolyl, or phenyl； X2 is phenyl or benzyl and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy； X3 is O or is absent； X4 is alkylene or alkenylene； X5 is O or is absent； and X6 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 halo or alkyl substituents； or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula I o fórmula II**Fórmula** en las que: R1 es -CON(R7)(Rs)； o R1 es pirroli
