The present application provides various devices, systems, and methods for removing stenotic lesions from vessels. In at least one embodiment of an exemplary device, the device comprises at least one sizing portion and at least one treatment portion. Such a device may be useful to, for example, remove a stenotic lesion from a vessel by positioning the device within a vessel lumen, operating the sizing portion to obtain luminal size parameter data, operating the treatment portion at a location within the vessel lumen at or near a stenotic lesion, and ceasing operation of the treatment portion when the luminal size parameter data indicates a preferred luminal size parameter.