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PHARMACEUTICAL COMBINATION THAT CONTAINS 6-DIMETHYLAMINOMETHYL-1- (3-METHOXY-Phenyl) -cyclohexane-1,3-DIOL AND PARACETAMOL
专利权人:
ГРЮНЕНТАЛЬ ГМБХ (DE)
发明人:
БЛОМС-ФУНКЕ Петра (DE),ШИНЕ Клаус (DE)
申请号:
RU2011112443/15
公开号:
RU2011112443A
申请日:
2009.09.04
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A combination that contains:! (a) at least one 6-dimethylaminomethyl-1- (3-methoxy-phenyl) -cyclohexane-1,3-diol component, and! (b) paracetamol or its derivative. ! 2. The combination according to claim 1, characterized in that component (a) is! ! optionally in the form of one of its stereoisomers, in particular the enantiomer or diastereomer, the racemate, or in the form of a mixture of its stereoisomers, in particular enantiomers and / or diastereomers in any ratio of the components in the mixture, or its salt. ! 3. The combination according to claim 1 or 2, characterized in that component (a) is (1RS, 3RS, 6RS) -6-dimethylaminomethyl-1- (3-methoxy-phenyl) -cyclohexane-1,3-diol or a salt thereof, where a hydrochloride salt or a phosphoric acid salt is preferred. ! 4. The combination according to claim 1, characterized in that the paracetamol derivative is selected from the group comprising propacetamol and phenidine. !5. The combination according to claim 1, characterized in that components (a) and (b) are presented in such a weight ratio that the composition exhibits a synergistic effect when administered to a patient. ! 6. A dosage form containing a combination in accordance with any one of claims 1 to 5. ! 7. The dosage form according to claim 6, characterized in that it is suitable for oral, intravenous, intraperitoneal, intradermal, intrathecal, intramuscular, intranasal, transmucosal, subcutaneous or rectal administration. ! 8. The dosage form according to claim 6 or 7, characterized in that one or both components (a) and (b) are presented (s) in a controlled release form. ! 9. The use of a combination according to any one of claims 1 to 5 for the treatment of one or more conditions selected from the group, in1. Комбинация, которая содержит: ! (а) по меньшей мере один 6-диметиламинометил-1-(3-метокси-фенил)-циклогексан-1,3-диольный компонент, и ! (б) парацетамол или его производное. ! 2. Комбинация по п.1, характеризующаяся тем, что компонент (а) пред
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