Cornell University;The UAB Research Foundation;Southern Research Institute
发明人:
Steven E. EALICK,William B. PARKER,Eric J. SORSCHER
申请号：
US14800864
公开号：
US20160022784A1
申请日:
2015.07.16
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a Trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a DNA sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-(β-D-arabinofuranosyl)-2-fluoroadenine (F-araA).
