Mary Elizabeth Pecquet Goad,Melissa M. Haskell,Denis Schrier,Susan A. Wood
申请号：
US13680381
公开号：
US20130288966A1
申请日:
2012.11.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-β superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.
