A system for inhibiting microbial growth by photocatalytic oxidation includes an intake having a first inlet port and a first outlet port, an air mover having a second inlet port and a second outlet port, and a filter having a third inlet port. An ultraviolet light source is disposed within the filter to promote photocatalytic oxidation of microbiological particles or other microbial growth, bioaerosols, volatile organic compounds or other particulate matter passing through the filter. The filter includes a filter body, a filter channel disposed within the filter body and having an outer surface and an inner surface. A filter media is disposed within the filter channel. A plurality of inlet ports is distributed over the inner surface and a plurality of outlet ports is distributed over the outer surface.