The Governing Council of the University of Toronto;Sinai Health System
发明人:
Benjamin J. Blencowe,Mathieu Quesnel-Vallieres,Manuel Irimia,Bushra Raj,Sabine P. Cordes
申请号：
US15536416
公开号：
US20170360873A1
申请日:
2015.12.15
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods for treatment and diagnosis of neurological disorders such as autism and autism spectrum disorder are disclosed. Also disclosed are modulators of alternative splicing regulators SRRM4 and/or SRRM3 for treating neurological disorders. Further disclosed are agents that modulate the expression of at least one splice variant for treating neurological disorders. Mouse models of neurological disorders having increased or decreased expression of SRRM4 and/or SRRM3 are also disclosed.
