Allen Radin;Ashique Rafique;Nicholas J. Papadopoulos;Sean Stevens;Eric Smith;James P. Fandl;Kevin J. Pobursky;Margaret Karow;Jeanette L. Fairhurst;Gang Chen;Joel H. Martin;Tammy T. Huang
发明人:
Allen Radin,Sean Stevens,Tammy T. Huang,Joel H. Martin,Jeanette L. Fairhurst,Ashique Rafique,Eric Smith,Kevin J. Pobursky,Nicholas J. Papadopoulos,James P. Fandl,Gang Chen,Margaret Karow
申请号：
US13286261
公开号：
US20120045440A1
申请日:
2011.11.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
