N V SATHEESH MADHAV,N V SATHEESH MADHAV,PREETI KOTHIYAL,PREETI KOTHIYAL,NEELIMA PANDEY,NEELIMA PANDEY
申请号：
IN283/DEL/2012
公开号：
IN2012DE00283A
申请日:
2012.02.01
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The current invention exposes a method for formulating Alprazolam nanoparticles using a mucoadhesive bio-retardant which was isolated from Vitis vinifera fruits. The biopolymer revealed its inbuilt functional groups C=O and N-H. The nanoparticles showed a size range of 10-97.5nm with a promising stability, dispersibility and retardability for a period of 48hrs and the nanoparticulate dispersion showed significant anti-depressant activity due to brain specificity. The biopolymer also revealed other inbuilt novelistic property bio-Retardability. Emulsifiability and Filmability, which was confirmed by suitably formulating drug delivery dosage forms. Conclusion was drawn that bio-nanoparticulate dispersion can be used for effectively targeting to the brain via nasal route and nanoparticulate can be prepared by a novel bio-excipient from Vitis vinifera and the biopolymer can also serve as a bio-excipient for formulating various drug delivery dosage forms.
