MIRKIN, CHAD A.,PALLER, AMY S.,GILJOHANN, DAVID A.
申请号：
CA2757694
公开号：
CA2757694C
申请日:
2010.03.15
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
The present disclosure relates to compositions and methods for delivering anoligonucleotide-functionalized nanoparticle. More specifically, the present disclosure relatesto a dermalcomposition for administration to the skin of a patient wherein thecomposition comprises adermal vehicle and a nanoparticle surface-functionalized with anoligonucleotide, wherein thedensity of oligonucleotide on the surface of the nanoparticle is at least 3pmol/cm2, and whereinthe nanoparticle is from about 10 nanometers (nm) to about 100 nm in meandiameter.
