PROBLEM TO BE SOLVED: To provide a separation membrane and a separation membrane module, that are suitable for use for which blood compatibility, non-adherence of proteins and organic substances, and non-elution of membrane constituents are required while maintaining a high separation performance.SOLUTION: The separation membrane is composed of at least three constituents including a polymer (A) composed of a hydrophobic unit polyvinyl pyrrolidone and/or polyethylene glycol (B) and a copolymer composed of a hydrophilic unit and a hydrophobic unit (C), wherein the solubility of (A) in pure water at 20°C is less than 1 g/100 g, the glass transition point of (B) is 90°C or more, and the solubility of (B) in pure water at 20°C is 10 g/100 g or more, and the glass transition point of (C) is 90°C or more, and the solubility of (C) in pure water at 20°C is 1 g/100 g or more, and wherein when the amount of absorption with respect to a film made of (A) at contact in water is denoted by Aw and the amount of absorption at contact in aqueous solution of 20 wt.% of acetonitrile is denoted by Aa, Aa/Aw is 0.95 or less, and wherein the abundance ratio of (B) and (C) is 5 wt.% or less, and (C) is present on the upper or lower surface of the separation membrane at a ratio of 5 wt.% or less.COPYRIGHT: (C)2015,JPO&INPIT【課題】高い分離性能を維持し、血液適合性やタンパク質や有機物の非付着、膜成分の非溶出が要求される分離膜および分離膜モジュールの提供。【解決手段】(A)疎水性ユニットからなる高分子、(B)ポリビニルピロリドンおよび/またはポリエチレングリコール、および、(C)親水性と疎水性ユニットからなる共重合体高分子、の少なくとも3成分から構成され、(A)は20℃の純水溶解度が1g/100g未満、(B)はガラス転移点が90℃以上、かつ、20℃の純水溶解度が10g/100g以上、(C)はガラス転移点が90℃以上、20℃の純水溶解度が1g/100g以上、かつ、(A)からなるフィルムに対し水中接触時の吸着量をAw、アセトニトリル20重量%混合水溶液中接触時の吸着量をAaとした場合、Aa/Awが0.95以下、(B)および(C)の存在比率は5重量%以下、(C)は上面または下面に5重量%以上存在している、分離膜。【選択図】図1