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TREATMENT OF Pancreatic cancer and non-small cell lung cancer with ATR inhibitors
专利权人:
ВЕРТЕКС ФАРМАСЬЮТИКАЛЗ ИНКОРПОРЕЙТЕД (US)
发明人:
ПОЛЛАРД Джон Роберт (GB),РИПЕР Филип Майкл (GB)
申请号:
RU2014117666/15
公开号:
RU2014117666A
申请日:
2012.10.01
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of treating pancreatic cancer in a patient by administering to the patient an ATR inhibitor selected in conjunction with another type of antitumor therapy selected from gemcitabine therapy, radiation therapy, or both gemcitabine therapies and radiation therapy together. A method for increasing the sensitivity of pancreatic cancer cells to antitumor therapy selected from gemcitabine therapy or radiation therapy in a patient by administering to the patient an ATR inhibitor selected in combination with antitumor therapy. 3. The method of claim 1, wherein the antitumor therapy is gemcitabine therapy. The method of claim 1, wherein the antitumor therapy is radiation therapy. A method for increasing the sensitivity of pancreatic cancer hypoxic cells to antitumor therapy selected from gemcitabine therapy or radiation therapy in a patient by administering to the patient an ATR inhibitor selected in conjunction with antitumor therapy. 6. A method of inhibiting phosphorylation of Chkl (Ser 345) in pancreatic cancer cells, comprising administering to the patient an ATR inhibitor selected in combination with gemcitabine and / or radiation. A method for radiosensitizing hypoxic pancreatic cancer cells by administering to a patient an ATR inhibitor selected in conjunction with radiation therapy. A method for increasing the sensitivity of pancreatic cancer hypoxic cells by administering to the patient an ATR inhibitor selected in combination with gemcitabine. A way to increase the sensitivity of pancreatic cancer cells to chemoradiotherapy1. Способ лечения рака поджелудочной железы у пациента посредством введения пациенту ингибитора ATR, выбранного изв сочетании с другим видом противоопухолевой терапии, выбранным из терапии гемцитабином, лучевой терапии или обеих терапий гемцитабином и лучевой терапии вместе.2. Способ повышения чувствительности клеток рака поджелудочной железы к противоопухолевой терапии, выбранной из терапии гемцитабином или лучевой терапии у пациента
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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