Methods are provided for treating mesothelioma patients with a dual PI3K/m TOR inhibitor, GDC-0980: (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno [3,2- d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, and having the structure:.Se proporcionan métodos de tratamiento de pacientes de mesotelioma con un inhibidor dual de PI3K/mTOR, que es el GDC-0980: (S)-1-(4-((2-(2-aminopirimidin-5-il)-7-metil-4-morfolino tieno[3,2-d]pirimidin-6-il)metil)piperazin-1-il)-2-hidroxipropan- 1-ona y tiene la estructura:.