multicomponent crystalline particles for inhalation therapy, pharmaceutical composition, dry powder inhaler, pressurized metered dose inhaler, methods of treating a respiratory disease or disorder or a lung disease or disorder in a patient, and of preparing the particles
Pharmaceutical Preparations Multi-component crystalline particles and compositions, methods for their preparation, their uses in inhalation therapy and inhaler devices containing said particles are provided, in particular particles comprising glycopyrrolate. The particles can be prepared substantially free of excipients and agents other than active agents or their precursors in the presence of ultrasonic irradiation in a process comprising contacting a solution in a first flowing stream with an anti-solvent in a re-circulating second flowing stream, causing the mixing thereof and collecting crystals that are generated.
