The present invention relates to a device for the removal of substances from blood and other fluids, said device comprising i) an electrocatalytic decomposition filter for removing substances such as toxins, toxic solutes, toxic small and middle-sized molecules and protein bound toxins from blood, blood plasma, ultrafiltrate or dialysate fluid, said electrocatalytic decomposition filter comprising a DC power source, a set of electrodes with a catalytic surface or in direct contact with sorbents offering catalytic activity, ii) an electrosorption filter for removing substances such as toxins, toxic solutes, toxic small and middle-sized molecules and protein bound toxins from blood, blood plasma, ultrafiltrate or dialysate fluid, said electrosorption filter comprising a DC power source, a set of electrodes, nanostructured sorption material and/or a porous polymer matrix, iii) an inlet for entry of blood or blood plasma or dialysate fluid into said device, iv) an outlet for the removal of purified blood, blood plasma, ultrafiltrate or dialysate fluid from said device, and v) a conduit connecting said inlet with said outlet and holding said electrosorption filter such that said blood, blood plasma, ultrafiltrate or dialysate fluid is forced through said electrosorption and electrocatalytic decomposition filter, and vi) a sensor and control system to safeguard the device from producing oxidative stress. The device of the present invention is also applicable for the purification of other fluids such as water, waste water, chemicals and other biofluids.La présente invention concerne un dispositif destiné à éliminer des substances du sang et d'autres fluides, ledit dispositif comprenant : i) un filtre de décomposition électrocatalytique pour éliminer des substances telles que des toxines, des solutés toxiques, des molécules toxiques de petite taille ou de taille moyenne et des toxines liées à des protéines, du sang, du plasma sanguin, d'un fluide de type ultrafiltrat ou dia
