用於治療Pim激酶相關病狀及疾病之噻唑啶二酮化合物农业专利-农业学术服务平台

发明人:: DAKIN, LESLIE,岱金　莱斯利,岱金　萊斯利,DOWLING, JAMES, EDWARD,道宁　詹姆士　艾德华,道寧　詹姆士　艾德華,LAMB, MICHELLE,兰姆　蜜雪儿,蘭姆　蜜雪兒,READ, JON,利德　强,利德　強,SU, QIBIN,苏启彬,蘇啟彬,ZHENG, XIAOLAN,郑晓兰,鄭曉蘭,岱金莱斯利,岱金萊斯利,道宁詹姆士艾德华,道寧詹姆士艾德華,兰姆蜜雪儿,蘭姆蜜雪兒,利德强,利德強

摘要：: The invention relates to chemical compounds of formula I,and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.本發明係關於式I化合物：及其鹽。在一些實施例中，本發明係關於Pim-1及/或Pim-2及/或Pim-3蛋白激酶活性或酶功能之抑制劑或調節劑。在其他實施例中，本發明係關於包含本文所揭示化合物的醫藥組合物，及其預防及治療Pim激酶相關病狀及疾病、較佳為癌症之用途。