An artificial physiological salt solution, wherein the active hydrogenreactionvalue is 0.01 to 1, the pH is 4.0 to 7.9 and the osmotic pressure is 260mOsm/L to 2560mOsm/L, as well as a manufacturing method for the same are provided as a novelartificial physiological salt solution, which has active oxygen eliminatingactivity andanti-inflammation effects, and can be appropriately used in a multitude ofapplicationssuch as organ cleaning solutions (cleaning solutions for the eyes, cleaningsolutions forthe nose and the like), artificial infusions, artificial amniotic fluid,protective solutions,cell/tissue cultures and the like, as well as a manufacturing method for thesame.