PROBLEM TO BE SOLVED: To provide novel methods and substances to prevent, alleviate or treat edema caused by various cause of disease.SOLUTION: Provided are isolated and substantially purified oligonucleotide compounds comprising a specified sequence, effective for alleviation of swelling and edema. The oligonucleotide compounds are administered in an effective amount and formulation to achieve one of the followings: regulation of vascular permeation, inhibition or reduction of leukocyte migration, inhibition or reduction of neutrophil migration or activation, inhibition or reduction of acidophil migration, and inhibition or reduction of lymphocyte migration. Also provided is an oligonucleotide of which at least one nucleotide has a phosphate backbone modification.【課題】様々な病因の浮腫を予防、軽減、または治療するための新規な方法及び物質の提供。【解決手段】腫脹及び浮腫の低下に有効である、特定の配列を含み、単離され、実質的に精製されたオリゴヌクレオチド化合物。前記オリゴヌクレオチド化合物は血管透過性の調節、白血球遊走の阻害又は低下、好中球遊走または活性化の阻害又は低下、好酸球遊走の阻害又は低下、及びリンパ球遊走の阻害又は低下の１つを達成するのに有効な量及び形態で投与する。少なくとも一つのオリゴヌクレオチドがリン酸骨格修飾を化学的に修飾されてなるオリゴヌクレチド。【選択図】図１
