An applicator device (1) comprises a top and a bottom layer (3, 5) of aflexible materialtightly connected at their borders. An edge constitutes a grip zone (26) tohandle the applicator (1). Parallelweakening lines (14, 16) in each layer (3, 5) define an application sectionand closely surround a pad (9,11) of a material capable to retain an agent (35) or an elevation (46)constituting a confmement structure foran agent (35). The superposition of weakening line and border of agentcarrying material or the elevationconstituting a part of the confinement structure avoids a contact of theflexible material with the surface (36)to be treated as the carrying material layer (9, 11) or the confinementstructure (46) serve as spacer means.As a consequence, the applicator is suited to be used on highly sensitivesurfaces like skin or mucosa.