HUGERTH ANDREAS,LINDELL KATARINA,THYRESSON KRISTINA,NICKLASSON FREDRIK
申请号：
NZ59899310
公开号：
NZ598993A
申请日:
2010.03.26
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
598993 Disclosed is a multi-portion intra-oral unitary dosage form (such as a lozenge, a tablet, an oral film, a sublingual tablet, a troche, a lolly pop, a hard boiled candy, a chocolate lens, a micro bead, a wine gum, a semi solid, or a combination thereof) comprising at least two portions, each of said two portions containing: (a) at least one pharmaceutically active agent or health promoting agent, wherein said agent is suitable for intra-oral administration, and (b) a different added flavouring agent, wherein said flavoring agent is different than said active agent or health promoting agent, and wherein said flavouring agent signals the user of said dosage form that said pharmaceutically active agent or health promoting agent has started to be released from said portion, and wherein (c) the two portions have different dissolution rates, and the dissolution time for the portion with the slower dissolution rate is at least two times longer than for the portion with the faster dissolution rate, and (d) the portion with the faster dissolution rate comprises (i) a compressible excipient selected from isomalt, dextrose monohydrate, maltodextrin, lactose monohydrate, dextrin, mannitol, lactitol, sorbitol, xylitol, erythritol, sucrose and lactose, and mixtures thereof, and (ii) a water swellable excipient selected from sodium starch glycolate, crospovidone, croscarmellose, microcrystalline cellulose, starches, hydroxypropyl cellulose and alginic acid, and mixtures thereof and (e) said intra-oral dosage form is not a chewing gum and does not contain a nicotine compound.
