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INHALED PARTICLES CONTAINING THIOTROPY
专利权人:
ЛАБОРАТОРИОС ЛИКОНСА; С.А. (ES)
发明人:
АМИГХИ Карим (BE),СЕРЕНО ГЕРРА Антонио (BE)
申请号:
RU2011117256/15
公开号:
RU2011117256A
申请日:
2009.10.02
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. Inhaled particles containing a stabilized anhydrous amorphous form of tiotropium and a stabilizing agent that is a sugar derivative. ! 2. Inhaled particles according to claim 1, where tiotropium contains tiotropium bromide. ! 3. Inhalable particles according to claim 1, where the sugar derivative is lactose. ! 4. Inhaled particles according to claim 1, having an average aerodynamic particle size of not more than 10 microns. ! 5. Inhaled particles according to claim 1, where the stabilized anhydrous amorphous form of tiotropium with a stabilizing agent contains a matrix in which tiotropium is distributed at the molecular level. ! 6. Inhaled particles according to claim 1, where the stabilized anhydrous amorphous form of tiotropium with a stabilizing agent contains amorphous tiotropium distributed over the surface of the stabilizing agent. ! 7. Inhaled particles according to claim 1, where the particles are mixed with one or more coarse fillers having an average particle size of from 15 microns to 250 microns. ! 8. Inhaled particles according to claim 7, where the coarse filler is lactose. ! 9. A pharmaceutical composition containing inhaled particles according to claim 5. ! 10. The pharmaceutical composition according to claim 9, where the content of tiotropium base is from 0.02% to 0.8%. ! 11. The pharmaceutical composition according to claim 9 in the form of a capsule for inhalation. ! 12. The pharmaceutical composition according to claim 11, where the capsule contains hydroxypropyl methylcellulose. ! 13. The method of producing respirable particles according to claim 1, comprising the following stages:! a) dissolving or dispersing the stabilizing agent in a volatile water-miscible solvent to form a solution or suspension; ! b) dissolution of the salt of tiotropium, or its sol1. Вдыхаемые частицы, содержащие стабилизированную безводную аморфную форму тиотропия и стабилизирующий агент, который представляет собой производное сахара. ! 2. Вдыхаемые частицы по п.1,
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