TSAO, NING,曹宁,曹寧,KUO, TSUNG-TIEN,郭聪田,郭聰田,YANG, DAVID J.,杨 敬文,楊 敬文,杨 敬文,楊 敬文
申请号：
TW107105450
公开号：
TW201836644A
申请日:
2018.02.14
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
A pharmaceutical formulation including a chelator-somatostatin receptor ligand and a transchelator is provided. The chelator-somatostatin receptor ligand is conjugated with a metal source or a radionuclide source, whereas the transchelator is capable of capturing free metal source or radionuclide source that is not conjugated to the chelator-somatostatin receptor ligand. By using such pharmaceutical formulation, the preparation of radiolabeled somatostatin analogues could be made more efficient, and is feasible for imaging of somatostatin receptor pathway-activated systems in cancers and neurological diseases. The present invention further provides a method of preparing the pharmaceutical formulation, and an imaging method using the pharmaceutical formulation.所提供的是一種包括螯合劑-生長抑制素受體配體與轉移螯合劑（transchelator）的醫藥調配物。該螯合劑-生長抑制素受體配體與金屬源或放射性核種源結合，而該轉移螯合劑能夠捕獲未結合至螯合劑-生長抑制素受體配體的自由金屬源或放射性核種源。藉由使用這樣的醫藥調配物，可使放射性標記的生長抑制素類似物的製備更有效率，並可用於癌症及神經疾病中生長抑制素受體途徑-活化系統的成像。本發明另提供製備上述醫藥調配物的方法，以及使用上述醫藥調配物的成像方法。
