Trevor J. McFarland;Binoy Appukuttan;J. Timothy Stout
发明人:
J. Timothy Stout,Trevor J. McFarland,Binoy Appukuttan
申请号：
US12134626
公开号：
US08748379B2
申请日:
2008.06.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Dominant negative (DN) variants of transcriptional enhancer factor 1-related (RTEF-1) are described. DN RTEF-1 polypeptides may be directly targeted to cells or delivered in nucleic acid expression vectors to alter cellular transcription. Methods for inhibiting VEGF production and thereby treating angiogenic disorders such as cancer are described. For example, in certain aspects, DN RTEF-1 may be used to treat angiogenic disorders of the eye such as age related macular degeneration (AMD).
