The United States of America; as Represented by The Secretary; Department of Health and Human Services
发明人:
ROSENBERG, Steven A.,GROS, Alena
申请号：
AU2019284080
公开号：
AU2019284080A1
申请日:
2019.12.24
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2019284080A120200123.pdf#####22 ABSTRACT Methods of obtaining acell population enriched for tumor-reactive Tcells, the method comprising: (a) obtaining abulk population of peripheral blood mononuclear cells (PBMCs) from asample of peripheral blood； (b) specifically selecting CD8 T cells thatialso express PD-1iand/or TIM-3 from the bulk population； and (c) separating the cells selected in (b) from unselected cells to obtain acell population enriched for tumor-reactive Tcells are disclosed.Related methods of administering acell population enriched for tumor-reactive T cells to amammal, methods of obtaining apharmaceutical composition comprising acell also disclosed.
