SHAPIRO, GARY,BROWEN, KEVIN,FINN, PATRICK,GREGORY, RICHARD C.,KODURI, RAO,LIU, FENG,MALKOVA, NATALIA,MANKOO, PARMINDER,POLLARD, JACK R.,QIU, HUAWEI,THEILHABER, JOACHIM,WINTER, CHRISTOPHER,YU, MARCELLA
申请号:
CA3050845
公开号:
CA3050845A1
申请日:
2018.01.19
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The invention provides an improved pan-TGF-ß antibody for treatment of conditions that are mediated by TGF-ß, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.