Gideon Gross,William J. Gibson,Dvir Dahary,Merav Beiman,Yael Sagi,Adi Sharbi-Yunger
申请号：
US16586730
公开号：
US20200316120A1
申请日:
2019.09.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides a method for identifying a target pair comprising i) an inhibitory chimeric antigen receptor (iCAR) or a protective chimeric antigen receptor (pCAR) capable of preventing or attenuating undesired activation of an effector immune cell, wherein the iCAR or pCAR target is directed to a target extracellular polymorphic epitope, and ii) an activating chimeric antigen receptor (aCAR), wherein the aCAR is directed to a target non-polymorphic cell surface epitope of a protein, as well as methods of making and use of such pairs in the treatment of cancer.
