A computed tomography perfusion phantom includes a scanned plane configured to align with an imaging plane of a CT device. A sample rod extends through the scan plane and includes a plurality of adjacent cells. The plurality of adjacent cells are each constructed of materials having predetermined CT numbers and the plurality of adjacent cells include cell of a plurality of CT numbers. A drive motor is coupled to the sample rod and the drive motor moves the sample rod through the scan plane. A method of calibrating a CT device with the perfusion phantom includes aligning the scan plane of the perfusion phantom with an imaging plane of the CT device. The drive motor moves the sample rod through the scan plane of the perfusion phantom. A plurality of CT number measurements of the sample rod are acquired through the scanned plane of the perfusion phantom.
