POLYPEPTIDES PRÉSENTANT UNE AFFINITÉ POUR LES PROTÉINES DE CHOC THERMIQUE (HSP) ET COMPLEXES ASSOCIÉS À UNE HSP (HACS) ET LEUR UTILISATION EN DIAGNOSTIC ET EN THÉRAPIE
NEW ENGLAND PEPTIDE, INC.;ATLANTIC CANCER RESEARCH INSTITUTE
发明人:
GRIFFITHS, STEVEN, GARETH,LEWIS, SCOTT, EDWIN
申请号：
EP12760787
公开号：
EP2688904A4
申请日:
2012.03.21
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present application is directed to a peptides comprising an a-helix forming-amino acid sequence that binds a heat shock protein. Also included is a polypeptide comprising (a) a first peptide portion that comprises an &alpha；-helix-forming amino acid sequence that binds a heat shock protein； and (b) at least one second peptide portion comprising an antigenic amino acid sequence and/or an a-helix-stabilizing amino acid sequence that increases the interaction of the first peptide portion with the heat shock protein. The present application also includes compositions comprising the peptides and/or polypeptides of present application and uses of the peptides and/or polypeptides of the present application for fractionating substances relevant for discovery, research or clinical analysis from a biological sample and as therapeutics.
