A medicament delivery tray and method of manufacture thereof for treating periodontal disease include an apparatus having a body formed to be fitted about all of the upper or lower teeth of a patient and having a top portion and an outer wall and an inner wall with each composed of resilient elastomeric material for substantially conforming to the enclosed teeth and gum tissue proximate to the teeth, the body having recesses, a treatment chamber and a raised seal formed about an inner surface of one of the skirts along a gum line and forming a substantially air tight seal thereto, and a port positioned on one of the skirts to receive a positive pressure from an external pressure source increasing a biasing force of the raised seal against the gum line when positive pressure is received through the port for sealing the chamber.
