Devices, systems, and methods for adjusting a prescription of a plurality of orthodontic brackets are disclosed herein. The devices include an orthodontic prescription-defining device that includes a plurality of contacting structures and a plurality of prescription-defining engagement structures. The systems include the orthodontic prescription-defining device and a plurality of orthodontic brackets. The methods include unlocking each of a plurality of orthodontic brackets, operatively contacting a plurality of contacting structures of an orthodontic prescription-defining device with a plurality of intra-oral reference points, urging each of a plurality of archwire slots to a respective preselected orientation, and locking each of the plurality of orthodontic brackets in the preselected orientation.
