Methods for treating a patient using therapeutic renal neuromodulation and associated devices, system, and methods are disclosed herein. One aspect of the present technology is directed to neuromodulating nerve tissue in selected anatomical regions. In one embodiment, a device includes a catheter having a first neuromodulation element operably connected to a shaft and a second neuromodulation element. The first neuromodulation element is configured to be located within a distalmost portion of a main vessel, and the second neuromodulation element is configured to be located within a branch vessel of the renal artery distal to a bifurcation of the main vessel. Neuromodulation of the nerve tissue surrounding the selected anatomical treatment locations can inhibit sympathetic neural activity in nerves proximate a portion of a renal artery or a renal branch artery proximate a renal parenchyma.
