Pharmaceutical or cosmetic preparation comprises hyaluronic acid, a retinoid or its salts and/or derivatives, an oligosaccharide and a hyaluronic acid degradation inhibitor, in a medium. Independent claims are included for: (1) a product comprising the components of the preparation as a combination product for simultaneous, separate or systematic use to treat dermatological disorders； and (2) the preparation of the pharmaceutical or cosmetic preparation comprising either mixing the components or a first stage of preparation of an injectable solution comprising the mixture of hyaluronic acid with a medium and a second stage of preparation of a topical composition comprising the mixture of the retinoid, its salts and/or derivatives with an oligosaccharide and a hyaluronic acid degradation inhibitor with a medium. ACTIVITY : Dermatological. MECHANISM OF ACTION : Hyaluronidase inhibitor. The ability of the hyaluronic acid degradation inhibitor was tested against bovine hyaluronidase activity. The results showed that glycyrrhizine exhibited an inhibition activity with an IC 5 0 value of 400 mu m.L'invention concerne une préparation pharmaceutique ou cosmétique pour application topique et/ou parentérale comprenant, dans un milieu physiologiquement acceptable, de l'acide hyaluronique, au moins un rétinoïde ou ses sels et dérivés, au moins un oligosaccharide, et au moins un inhibiteur de la dégradation de l'acide hyaluronique. L'invention s'applique en particulier en dermatologie humaine ou en chirurgie réparatrice.
