An endotracheal tube comprises a main lumen for delivering a breathing gas into a lung of a patient, and a cuff, mounted at a distal end of the endotracheal tube, to be located in the subglottal region of the patient. The endotracheal tube also comprises a cuff inflation lumen for inflating the cuff, and at least three additional lumens, other than the main lumen and the cuff inflation lumen, configured for delivering liquid to the subglottal region, for suctioning liquid from the subglottal region, and for venting the subglottal region.