GERALDINE C. HARRIMAN,SHOMIR GHOSH,SILVANA MARCEL LEIT DE MORADEI
申请号：
BR112018008227
公开号：
BR112018008227A2
申请日:
2016.10.26
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
This application provides compounds useful as inhibitors of acetyl CoA carboxylase (ACC), compositions thereof, and Methods of Use thereof.Claim 1: a compound of formula (1) or (2), or a pharmaceutically acceptable Salt, or a mixture of stereoisomers of stereoisomer, where X is selected from: - O -, - S -,Or - N (R) - q\u00b9 each is independently and q\u00b2 o or s r\u00b9 is Hydrogen, halogen, - CN, - no\u2082, r\u2076 -, - or, or - R\u00b2 is Hydrogen, halogen or r\u2076, -, -, -, - N (R) - N (\u2082, (R) R, - C (o) C (o) n (R) \u2082, N (R) - C (o) n (R) \u2082,N - (R) - C (o) or oC (o) n (R) \u2082.N (R) - S (o) \u2082r - S (o), (R) \u2082n \u2082, - R, - C (o) C (o) or oC (R, S) - or (R, S) - and (OR) \u2082r,Or Hy or r\u00b9 and R\u00b2 can optionally be taken together to form a carbociclo monocyclic - 3 - 8 members optionally replaced partially saturated or unsaturated, or a benzo heterocycle -, -Or a heteroaryl FUSED Ring of 5-6 members there is a Ring of a Ring selected optionally substituted monocyclic Heterocyclic 3 - 8 members or partially saturated unsaturatedHave 1 - 4 regardless of nitrogen heteroatoms selected,Oxygen and sulfur a monocyclic heteroaryl Ring of 5 - 6 members that have 1-4 independently heteroatoms selected from Oxygen, nitrogenA bicyclic Heterocyclic ring and sulfur partially saturated or unsaturated 6 to 10 members with 1 - 5 regardless of nitrogen heteroatoms selected,Oxygen and sulfur bicyclic heteroaryl ring and a 7 - 10 members with 1 - 5 regardless of nitrogen heteroatoms selected,Oxygen and sulfur each is independently selected from Hydrogen, deuterium,And a group of c\u2081\u208b\u2086 selected optionally substituted aliphatic carboc\u00edclico monocyclic Ring a 3 - 8 members or partially saturated unsaturated phenyl bicyclic aryl Ring a 8 - 10 member of monocyclic Heterocyclic Ring a 3 - 8 members partially unsaturated or saturated with 1 - 4 heteroatoms selected irrespective of nitrogenOxygen and sulfur a monocyclic heteroar
