Disclosed are oral care compositions, for example dentifrice compositions, comprising an oral care composition comprising an orally acceptable vehicle, metal oxide particles having an average particle size of no greater than a dentin tubule and at least one amino acid capable of chelating the metal oxide. The composition may comprise a polymeric adherent material for adhering the metal oxide particles in the dentin tubule. The metal oxide particles have a median particle size of 5 microns or less, and may comprise zinc oxide.揭示口腔保健組成物，例如潔牙劑組成物，其包含一含有口服可接受之載體、具有平均粒度不大於齒質小管的金屬氧化物粒子，以及至少一種能夠螯合金屬氧化物之胺基酸的口腔保健組成物。該組成物可包含一聚合黏著材料供用於將金屬氧化物粒子黏附至齒質小管中。金屬氧化物粒子具有中位平均粒度為5微米或更小，並且可含有氧化鋅。
