The invention relates to a formulation cancer drug termed the “medicinal ion bomb” and its treatment methods. A mouse carcinoma, at 13mm x 13mm in size was killed by a single intratumoral injection with 0.14±ml of the “medicinal ion bomb”. In selected human patient a solid cancer at 50mm ×70mm in size was killed by one single intratumoral injection with 3.5±ml of the “medicinal ion bomb”. The invention can be used as the first-line treatment of human cancer, in skin and subcutaneous tissue, brain, thyroid, breast, lung, liver, pancreas, prostate, and genital organs. The invention can also be used as the first-line treatment of human benign diseases of skin and subcutaneous neoplasm, breast fibrocystic change, benign prostatic hyperplasia and thyroid nodule.