COMPOSITIONS COMPRISING C-13 ALKOXYETHER MACROLIDE COMPOUNDS AND PHENYLPYRAZOLE COMPOUNDS

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专利权人:

MERIAL LIMITED

发明人:

SOLL, MARK D.,BOECKH, ALBERT,SHUB, NATALYA

申请号：

CA2684926

公开号：

CA2684926C

申请日:

2007.05.03

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

Provided is a novel ivermectin derivative and compositions for the treatment or prophylaxis of parasite infestations in mammals or birds which comprise: (A) a pharmaceutically effective amount of a 1-N-phenylpyrazole compound (B) a pharmaceutically effective amount of an ivermectin derivative of formula (II) wherein: R14 represents -(CH2)S-O-Z wherein, s is 1 or 2 Y represents -CH(OR, 15)-, -C(=O)- or -C(=NOR 15) R15 represents hydrogen, alkyl or phenyl and R16 represents -CH3 or -CH2CH3 Z is alkyl, alkenyl, alkynyl, acyl, alkylalkoxy, aryl, alkanoyloxy, alkoxycarbonyl, alkenoyl, alkynoyl, or aroyl.

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