SINGH, RAJINDER,LI, HUI,ZHAO, HAORAN,PAYAN, DONALD G,KOLLURI, RAO,TSO, KIN,RAMPHAL, JOHN,GU, SHIHAI
申请号：
NZ58248508
公开号：
NZ582485A
申请日:
2008.07.17
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a pyrimidine compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are: 5-Fluoro-N2-[3-methoxy-5-(1H-1,2,3,4-tetrazol-1-yl)]phenyl-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-2,4-pyrimidine diamine N2-[3-Methoxy-5-(1,2,3,4-tetrazol-1-yl)]phenyl-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-5-trifluoromethyl-2,4-pyrimidine diamine and 5-Fluoro-N4-(1,2,2,6, 6-pentamethylpiperidin-4-yl)-N2-(3-tetrazol-1-yl)phenyl-2,4-pyrimidine diamine. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating inflammatory or immune disorder, asthma, atopic dermatitis, allergic rhinitis, systemic anaphylaxis, hypersensitivity responses, drug allergies, insect sting allergies, dermatitis, eczema, urticaria, inflammatory bowel disease, Crohns disease, ileitis, Celiac disease, non-tropical Sprue, enteritis, enteropathy, colitis, eosinophilic gastroenteritis, ileoanal anastomosis, disorders of the skin, multiple sclerosis, systemic lupus erythermatosus, myasthenia gravis, juvenile onset diabetes, glomerulonephritis, autoimmune thyroiditis, Behcets disease, graft rejection, stroke, cardiac ischemia, mastitis, vaginitis, cholecystitis, cholangitis, chronic bronchitis, chronic sinusitis, chronic inflammatory diseases of the lung, hypersensitivity pneumonitis, collagen diseases, sarcoidosis, vasculitis, spondyloarthropathies, scleroderma, atherosclerosis, restenosis, myositis pancreatitis, insulin-dependent diabetes mellitus, autoimmune thrombocytopenia, rheumatoid arthritis, osteoarthritis, multiple sclerosis, inflammatory bowel disease, psoriasis, organ transplantation, graft vs. host disease, asthma, chronic obstructive pulmonary disease, osteoarthritis, multiple sclerosis, psoriasis, organ transplantation, insulin-dependent diabetes, a metabolic disorder, insulin resistance, metabolic syndrome, or type I
