The present invention provides a system and method for determining sudden heart attack of a driver, which can be used to determine whether the driver of the vehicle had a sudden heart attack, comprising the steps of: first, continuously acquiring the drivers physiological signals of respiratory rate, heart rate, blood pressure and the like, and sending them to a monitoring system one processor of the monitoring system using artificial neural network techniques to train the physiological signals for establishing a plurality of personal models exclusively for the driver, each personal model having a threshold from the recently captured physiological signals to determine whether there is any physiological signal exceeding the threshold, if there is at least one physiological signal exceeding the threshold, the monitoring system will be based on the type of physiological signals that exceed the threshold to determine the risky level of drivers status and issue an alarm.本發明提供一種駕駛者突發性心臟病判斷系統及方法,其用以判斷車輛之駕駛人是否有突發性心臟病,先持續擷取駕駛者之呼吸頻率、心律及血壓等生理訊號,並傳送到一監控系統,監控系統中之一處理器利用類神經網路技術將生理訊號分別訓練建立出專屬於駕駛者之複數個人化模型,每一個人化模型具有一閥值;再判斷最近擷取的生理訊號中是否有任一種生理訊號超出閥值,若生理訊號中有至少一種超出閥值,則監控系統會依據超出閥值之生理訊號之種類數,判斷駕駛者之狀態危險程度,並發出警示。10‧‧‧駕駛者突發性心臟病判斷系統12‧‧‧感測器122‧‧‧呼吸頻率感測器124‧‧‧心律感測器126‧‧‧血壓感測器14‧‧‧監控系統142‧‧‧處理器144‧‧‧記憶體150‧‧‧個人化模型152‧‧‧呼吸頻率模型154‧‧‧心律模型156‧‧‧血壓模型