The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.本發明提供投與因子VIII(經加工之FVIII、單鏈FVIII或其組合)之方法;投與包含因子VIII之嵌合及雜交多肽之方法;包含因子VIII之嵌合及雜交多肽;編碼該等嵌合及雜交多肽之多核苷酸;包含該等多核苷酸之細胞;及使用該等細胞製備該等嵌合及雜交多肽之方法。